Chemical Engineering (CHE)

CHE 001 Coffee and Cosmetics 3 Credits

This course will focus on developing processes for creating coffee and cosmetics that overlap with core principles of chemical engineering. Coffee will introduce students to basic concepts of process design and scale-up and the ideas of "unit operations" that that are performed such as roasting, grinding, and filtration. Cosmetics will introduce the basic principles of rheology, surface energy, and other concepts that surround "squishy" materials. These everyday goods will bring new light to the interface of engineering and consumer products.

CHE 031 Material and Energy Balances of Chemical Processes 0,3 Credits

Material and energy balances with and without chemical reaction. Introduction to phase equilibrium calculations. Applications in chemical process calculations and in design of staged separations: binary distillation, liquid-liquid extraction.
Prerequisites: ENGR 010 and (CHM 030 or CHM 040)
Can be taken Concurrently: ENGR 010, CHM 030, CHM 040

CHE 044 Fluid Mechanics 0,3 Credits

Fluid mechanics and its applications to chemical processes. Momentum and energy balances in fluid flow. Dimensional analysis. Fluid flow in pipes, packed and fluidized beds. Mixing and agitation. Filtration and sedimentation.

CHE 085 Undergraduate Research 1 Credit

Independent study of a problem involving laboratory investigation, design, or theoretical studies under the guidance of a faculty. Consent of the department chair.
Repeat Status: Course may be repeated.

CHE 144 Fluid Mechanics 3 Credits

Fluid mechanics and its applications to chemical processes. Momentum and energy balances in fluid flow. Dimensional analysis. Fluid flow in pipes, packed and fluidized beds. Mixing and agitation. Filtration and sedimentation. Credit will not be granted for both CHE 044 and CHE 144.

CHE 151 Heat and Mass Transfer 0,3 Credits

Fundamental principles of heat and mass transfer. The three modes of heat transfer are taught: conduction, convection and radiation. The physical principles of mass transfer are taught including diffusion and convection. Parallels and relationships between heat and mass transfer are highlighted. Fundamental principles of heat and mass transfer are applied to the analysis and design of unit operations including heat exchangers and mass separators.
Prerequisites: CHE 031 and CHE 044 and CHE 210

CHE 171 (CEE 171, EMC 171) Fundamentals of Environmental Technology 4 Credits

Introduction to water and air quality, water, air and soil pollution. Chemistry of common pollutants. Technologies for water purification, wastewater treatment, solid and hazardous waste management, environmental remediation, and air quality control. Global changes, energy and environment. Constraints of environmental protection on technology development and applications. Constraints of economic development on environmental quality. Environmental life cycle analysis and environmental policy. Not available to students in RCEAS.

CHE 179 Professional Development 1 Credit

Elements of professional growth, registration, ethics, and the responsibilities of engineers both as employees and as independent practitioners. Proprietary information and its handling. Patents and their importance. Discussions with the staff and with visiting Lecturers. A few plant trips.

CHE 185 Undergraduate Research I 1-3 Credits

Independent study of a problem involving laboratory investigation, design, or theoretical studies under the guidance of a faculty member.
Repeat Status: Course may be repeated.

CHE 186 Undergraduate Research II 1-3 Credits

A continuation of the project begun under CHE 185. Consent of department chair.
Repeat Status: Course may be repeated.
Prerequisites: CHE 185

CHE 201 Methods of Analysis in Chemical Engineering 0,4 Credits

Analytical and numerical methods of solution applied to dynamic, discrete and continuous chemical engineering processes. Laplace Transforms. MATLAB based computations. Methods of analysis applied to equilibrium, characteristic value and non-linear chemical engineering problems.
Prerequisites: CHE 044 and CHE 210 and MATH 023 and MATH 205
Can be taken Concurrently: MATH 205

CHE 202 Chemical and Biomolecular Engineering Laboratory I 0,3 Credits

The laboratory study of chemical engineering unit operations and the reporting of technical results. One three-hour laboratory and one lecture period per week. Independent study and both group and individual reporting.
Prerequisites: CHE 151 and CHE 211 and CHE 244

CHE 203 Chemical and Biomolecular Engineering Laboratory II 3 Credits

Laboratory experience with more complex chemical processing situations including processes involving chemical reactions and those controlled automatically.
Prerequisites: CHE 202

CHE 210 Chemical Engineering Thermodynamics 0,3 Credits

Energy relations and their application to chemical engineering. Consideration of flow and nonflow processes. Evaluation of the effects of temperature and pressure on the thermodynamic properties of fluids. Heat effects accompanying phase changes and chemical reactions. Determination of chemical and physical equilibrium.
Prerequisites: CHE 031 and MATH 023

CHE 211 Chemical Reactor Design 0,3 Credits

The theory of chemical kinetics to the design and operation of chemical reactors. Plug flow and continuous stirred tank reactors. Homogeneous and heterogeneous reaction kinetics. Design of isothermal and adiabatic reactors.
Prerequisites: CHE 210

CHE 212 Physical Chemistry for Engineers 0,3 Credits

Thermodynamics of phase and reaction equilibria. Quantum theory and molecular spectroscopy. Reaction kinetics in homogeneous and heterogeneous systems. Fundamentals of Electrochemistry. Physical chemistry of colloidal systems.
Prerequisites: CHE 210 or ME 104

CHE 231 Biomolecular Engineering 3 Credits

Application of quantitative chemical engineering concepts to biological systems. Topics include kinetic and thermodynamic contributions to protein-ligand binding, enzyme kinetics, gene expression, protein trafficking, and cell growth.
Prerequisites: CHE 031 and (CHE 210 or BIOE 246 or MAT 205 or ME 104)

CHE 233 Process Design I 0,3 Credits

Design of chemical plants incorporating traditional elements of engineering economics and synthesis of steady-state flowsheets with (1) both heuristic and rigorous optimization methods and (2) consideration of dynamic controllability of the process. Economic principles involved in the selection of process alternatives and determination of process capital, operating costs, and venture profitability. Energy conservation, pinch techniques, heat exchanger networks, and separation sequences. Considerations of market limitations, environmental and regulatory restrictions, and process safety. Use of modern computer aided software for steady-state and dynamic simulation and optimization. Group design projects.
Prerequisites: (CHE 211 and CHE 242 and CHE 244)
Can be taken Concurrently: CHE 242

CHE 234 Process Design II 0,3 Credits

Continuation of CHE 233.
Prerequisites: CHE 233
Can be taken Concurrently: CHE 233

CHE 242 Introduction to Process Control and Simulation 0,3 Credits

Dynamic simulation of chemical processes. Transfer functions and block diagrams. Introduction to process control equipment. Open-loop and closed-loop stability analysis using root locus and Nyquist techniques. Design of control systems.
Prerequisites: CHE 201 and CHE 151 and ENGR 010

CHE 244 Separation Processes 0,3 Credits

Staged and continuous separations. Phase equilibrium. Binary and Multicomponent Distillation. Liquid-liquid extraction. Review of applied diffusion processes, atmospheric dispersion, jets and plumes. Membranes in gas and liquid systems. Adsorption and Ion Exchange Separations. Chromatographic Separations. Introduction to Bioseparations. Introduction to Aspen Programming.
Prerequisites: CHE 031 and CHE 044 and CHE 210 and CHE 151

CHE 280 Unit Operations Survey 3 Credits

The theory of heat, mass and momentum transport. Laminar and turbulent flow of real fluids. Heat transfer by conduction, convection and radiation. Application to a wide range of operations in the chemical and metallurgical process industries.

CHE 281 Chemical Engineering Fundamentals I 4 Credits

Fundamentals of material balances, fluid mechanics and heat transfer. Must have undergraduate degree in a scientific or engineering discipline or one semester undergraduate level general chemistry, one semester undergraduate level physics (statics and dynamics), and two semesters undergraduate calculus. Consent of department required.

CHE 282 Chemical Engineering Fundamentals II 4 Credits

Fundamentals of heat and mass transfer, process energy balances and unit operations. Consent of department required.
Prerequisites: CHE 281

CHE 300 Apprentice Teaching 1-4 Credits

Repeat Status: Course may be repeated.

CHE 306 Introduction to Biomedical Engineering and Mathematical Biology 3 Credits

Study of human physiology, including the cardiovascular, nervous and respiratory systems, and renal physiology. Mathematical analysis of physiological processes, including transport phenomena. Mathematical models of excitation and propagation in nerve. Biomechanics of the skeletal muscle system. Mathematical models in population dynamics and epidemiology. Independent study projects.
Prerequisites: MATH 205

CHE 318 (BIOE 318, MAT 318) Soft Materials: Rheology and Characterization 3 Credits

Characterization of soft materials using rheological techniques. Fundamentals of rheology and rheological characterization applied to materials such as polymers, glassy liquids and polymeric gels. Closed to students who have taken CHE/BIOE/MAT 418. Instructor permission or graduate status required.

CHE 321 Biomolecular & Cellular Mechanics 3 Credits

Mechanics and physics of the components of the cell, ranging in length scale from fundamental biomolecules to the entire cell. Thecourse covers the mechanics of proteins and other biopolymers in 1D, 2D, and 3D structures, cell membrane structure and dynamics, and the mechanics of the whole cell.
Prerequisites: MATH 205 and MATH 231 and PHY 022 and (PHY 013 or PHY 021)

CHE 331 Separation Processes 3 Credits

Industrial separation chemistry and processes. Computer solutions for simple and complex multicomponent distillation columns. Azeotropic and extractive distillation. Adsorption, ion exchange and chromatography in packed beds, moving beds and cyclic operation. Synthesis of polymer membrane and its applications to industrial separation processes.

CHE 334 (MAT 334) Electron Microscopy and Microanalysis 4 Credits

Fundamentals and experimental methods in electron optical techniques including scanning electron microscopy (SEM), conventional transmission (TEM) and scanning transmission (STEM) electron microscopy. Specific topics covered will include electron optics, electron beam interactions with solids, electron diffraction and chemical microanalysis. Applications to the study of the structure of materials are given. Consent of department required.

CHE 339 Neuronal Modeling and Computation 3 Credits

Neuroscience in a computational, mathematical, and engineering framework. Literature surveys and case studies with simulations. Computational aspects of information processing within the nervous system by focusing on single neuron modeling. Single neurons and how their biological properties relate to neuronal coding. Biophysics of single neurons, signal detection and signal reconstruction, information theory, population coding and temporal coding.
Prerequisites: ENGR 010 and MATH 205

CHE 341 (BIOE 341) Biotechnology I 3 Credits

Applications of material and energy balances; heat, mass, and momentum transfer; enzyme and microbial kinetics; and mathematical modeling to the engineering design and scale-up of bio-reactor systems. Closed to students who have taken CHE 441 (BIOE 341 and BIOE 441).
Prerequisites: MATH 205 and CHE 031 and (CHM 031 or CHM 041)

CHE 342 (BIOE 342) Biotechnology II 3 Credits

Engineering design and analysis of the unit operations used in the recovery and purification of products manufactured by the biotechnology industries. Requirements for product finishing and waste handling will be addressed. Closed to students who have taken CHE 442 (BIOE 342 and BIOE 442).
Prerequisites: MATH 205 and CHE 031 and (CHM 031 or CHM 041)

CHE 344 (BIOE 344) Molecular Bioengineering 3 Credits

Kinetics in small systems, stochastic simulation of biochemical processes, receptor-mediated adhesion, dynamics of ion-channels, ligand binding, biochemical transport, surface Plasmon resonance, DNA microarray design, and chemical approaches to systems biology. Senior standing in ChE.
Prerequisites: MATH 205 and MATH 231

CHE 345 (BIOE 345) Quantitative Biology 3 Credits

Basic concepts in molecular and cellular biology as well as biochemistry. Connects these to engineering principles to (1) develop a quantitative understanding of biological systems and (2) understand how modern engineering uses applications of methods and principles in biology. Topics include quantity and length scales in biology, use of statistical mechanics to describe phenomena such as microstates and ligand receptor binding, and application of chemical reaction kinetics to describe biochemical reactions. Closed to students who have taken BIOE 445.
Prerequisites: MATH 205

CHE 346 Biochemical Engineering Laboratory 0,3 Credits

Laboratory and pilot-scale experiments in fermentation and enzyme technology, tissue culture, and separations techniques. Consent of instructor required. Closed to students who have taken CHE 446.
Prerequisites: CHE 341
Can be taken Concurrently: CHE 341

CHE 350 Special Topics 1-3 Credits

A study of areas in chemical engineering not covered in courses presently listed in the catalog.
Repeat Status: Course may be repeated.

CHE 363 (BIOE 363) Numerical Methods for Scientists and Engineers 3 Credits

Introduction to numerical methods in science and engineering. Expose students to the numerical solution of a variety of commonly encountered problems, enhance their numerical programming skills, and provide a broad base on which to build more specialized knowledge of computational methods. Topics include solution of linear and nonlinear sets of algebraic equations, linear and logistic regression, ordinary differential equations, Fourier analysis, eigenvalues, partial differential equations by finite difference and finite element methods.
Prerequisites: MATH 205

CHE 365 Molecular Modeling and Simulation 3 Credits

Introduction to molecular modeling and simulation techniques. Expose students to programming environments and give a broad overview of molecular simulation methods used in chemical engineering. Topics include density functional theory including periodic systems, molecular dynamics, Monte Carlo techniques, review of statistical mechanics and ensembles, biased sampling and free energy methods, and microkinetic modeling. Student will use existing software as well as develop their own computer codes in this class.

CHE 367 (BIOE 367) Engineering in Medicine 3 Credits

Introduction to the physical basis of disease. Discussion of biomolecular strategies to overcome these changes. Topics include drug delivery, targeting, and tissue engineering, with a focus on infectious disease, cancer, cardiovascular disease, and neurodegenerative disease. Closed to students who have taken CHE 467 (BIOE 367 and BIOE 467).

CHE 369 (BIOE 369) Advanced Topics in Regulatory Affairs 3 Credits

Regulatory requirements for the development and manufacture of 21st century medical products. Current challenges and innovative technologies in pharmaceuticals and medical devices. Topics include combination products, biosimilars, cell therapeutics, mobile medical applications, 3D-printed products, big data in healthcare, new approaches to process validation. Closed to students who have taken BIOE/CHE 469.
Prerequisites: BIOE 225

CHE 370 (BIOE 370) The Engineering of Brewing, Winemaking, and Distilling 0,3 Credits

An open-ended and experiential exploration of the engineering principles required for the brewing of beer, winemaking, and distilling of spirits.
Prerequisites: (BIOE 341 or CHE 211) and (BIOE 246 or CHE 212)

CHE 373 (CEE 373) Fundamentals of Air Pollution 3 Credits

Introduction to the problems of air pollution including such topics as: sources and dispersion of pollutants; sampling and analysis; technology of economics and control processes; legislation and standards. Must have senior standing in the College of Engineering and Applied Science.

CHE 374 Environmental Catalysis 3 Credits

Pollution emissions in the USA (NOx, SOx, NH3, CO, VOCs, PM, heavy metals and persistent bioaccumulative chemicals) and their sources and fate. Fundamental concepts of catalysis (surface and their characterization, physical adsorption, surface reaction mechanisms and their kinetics). Application of catalysis to a wide range of environmental issues (catalytic combustion of VOCs, automotive catalytic converter, selective catalytic conversion of NOx, etc.) Must have senior standing. Consent of instructor required.

CHE 375 (CEE 375) Environmental Engineering Processes 3 Credits

Fundamental physical, chemical and microbiological processes applied in environmental engineering for air pollution control, treatment of drinking water, municipal wastewater, industrial wastes, hazardous/toxic wastes, and environmental remediation. Kinetics, reactor theory, mass balances, application of fundamental physical, chemical and microbiological principles to analysis and design.
Prerequisites: CEE 170 and CHM 031

CHE 376 (ME 376) Energy: Issues & Technology 3 Credits

Energy usage and supply, fossil fuel technologies, renewable energy alternatives and environmental impacts. The scope will be broad to give some perspective of the problems, but in-depth technical analysis of many aspects will also be developed.
Prerequisites: CHE 210 or ME 104 or CHM 342 or MAT 205

CHE 377 Electrochemical Engineering 3 Credits

Fundamental concepts of electrochemistry, covering the thermodynamics, kinetics, and transport phenomena that occur in both liquid and solid state electrochemical systems. This course draws upon concepts from physical chemistry, chemical engineering and materials science to address the phenomena that govern the performance of electrochemical devices, and that drive important engineering phenomena such as corrosion. The course will serve as a basis for a career in electrochemistry as it applies to energy issues. Prerequisites: Senior level in ChE or instructor approval.

CHE 379 Senior Thesis 3 Credits

Two-semester, independent study of a research problem under the guidance of a faculty advisor and thesis committee. Written thesis proposal and oral presentation required in first semester, and a written final thesis and oral presentation required at the end of the second semester. Students will receive a certificate upon graduation with the thesis title, signed by the advisor and department chair. Must have senior standing in Chemical and Biomolecular Engineering. Consent of department required.
Repeat Status: Course may be repeated.

CHE 380 Senior Research Project (OSI) 1-6 Credits

Independent study of a problem involving laboratory investigation, design, and theory, when possible involves one of the local communities or industries. Team work under the guidance of Faculty advisors. Experiential learning opportunity to bridge educational gap between conventional textbook learning and industrial approaches to real-world technical problem solving. Must have senior standing. Consent of department required.
Repeat Status: Course may be repeated.

CHE 383 Chemical Engineering Fundamentals III 4 Credits

Fundamentals of thermodynamics, reaction kinetics and reactor analysis, and applied mathematics. Consent of department required. Cannot apply towards a Chemical Engineering undergraduate degree.
Prerequisites: CHE 282

CHE 386 Process Control 3 Credits

Open-loop and closed-loop stability analysis using root locus and Nyquist techniques, design of feedback controllers with time and frequency domain specifications. Experimental process identification. Control of multivariable processes. Introduction to sampled-data control theory.
Prerequisites: CHE 242

CHE 387 (ECE 387, ME 387) Digital Control 3 Credits

Sampled-data systems; z-transforms; pulse transfer functions; stability in the z-plane; root locus and frequency response design methods; minimal prototype design; digital control hardware; discrete state variables; state transition matrix; Liapunov stability state feedback control (2 lectures and one laboratory per week).
Prerequisites: CHE 386 or ECE 212 or ME 343

CHE 388 (CHM 388, MAT 388) Polymer Characterization 3 Credits

Description of molecular weight measurements using dilute solutions (solution viscosity, size exclusion chromatography, osmotic pressure, and light scattering). Introduction to polymer thermal analysis techniques such as differential scanning calorimetry (DSC) , dynamic mechanical analysis (DMA), and thermomechanical analyzer (TMA). Discussion of structure and morphology of polymers and polymer blends using nuclear magnetic resonance (NMR), infrared spectroscopy (IR), Raman spectroscopy, UV analysis, transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM). Crystallinity measurements using SANS, SAXS, and WAXS.
Prerequisites: MAT 033 or MAT 204 or MAT 392 or MAT 393

CHE 389 (ECE 389, ME 389) Control Systems Laboratory 2 Credits

Experiments on a variety of mechanical, electrical and chemical dynamic control systems. Exposure to state-of-the-art control instrumentation: sensors, transmitters, control valves, analog and digital controllers. Emphasis on comparison of theoretical computer simulation predictions with actual experimental data. Lab teams will be interdisciplinary.
Prerequisites: CHE 242 or ECE 212 or ME 343

CHE 391 (CHM 391) Colloid and Surface Chemistry 3 Credits

Physical chemistry of everyday phenomena. Intermolecular forces and electrostatic phenomena at interfaces, boundary tensions and films at interfaces, mass and charge transport in colloidal suspensions, electrostatic and London forces in disperse systems, gas adsorption and heterogeneous catalysis. Consent of instructor required.

CHE 392 (MAT 392) Introduction to Polymer Science 3 Credits

Introduction to concepts of polymer science. Kinetics and mechanism of polymerization, synthesis and processing of polymers, characterization. Relationship of molecular conformation, structure and morphology to physical and mechanical properties.

CHE 393 (CHM 393, MAT 393) Physical Polymer Science 3 Credits

Structural and physical aspects of polymers (organic, inorganic, natural). Molecular and atomic basis for polymer properties and behavior. Characteristics of glassy, crystalline, and paracrystal-line states (including viscoelastic and relaxation behavior) for single-and multi-component systems. Thermodynamics and kinetics of transition phenomena. Structure, morphology, and behavior. Available to graduate and undergraduate students (with senior level standing) in CHE, CHEM or MAT.

CHE 394 (CHM 394) Organic Polymer Science I 3 Credits

Organic chemistry of synthetic high polymers. Polymer nomenclature, properties, and applications. Functionality and reactivity or monomers and polymers. Mechanism and kinetics of step-growth and chain-growth polymerization in homogenous and heterogenous media. Brief description of emulsion polymerization, ionic polymerization, and copolymerization. Must have completed one year of physical chemistry and one year of organic chemistry.
Prerequisites: CHM 031 or CHM 041 or CHM 110 or CHM 112 or CHM 342 or CHE 210
Attribute/Distribution: NS, Q

CHE 400 Chemical Engineering Thermodynamics 3 Credits

Applications of thermodynamics in chemical engineering. Topics include energy and entropy, heat effects accompanying solution, flow of compressible fluids, refrigeration including solution cycles, vaporization and condensation processes, and chemical equilibria. Must have completed an introductory course in thermodynamics.

CHE 401 Chemical Engineering Thermodynamics II 3 Credits

A detailed study of the uses of thermodynamics in predicting phase equilibria in solid, liquid, and gaseous systems. Fugacities of gas mixtures, liquid mixtures, and solids. Solution theories; uses of equations of state; high-pressure equilibria.

CHE 410 Chemical Reaction Engineering 3 Credits

The application of chemical kinetics to the engineering design and operation of reactors. Non-isothermal and adiabatic reactions. Homogeneous and heterogeneous catalysis. Residence time distribution in reactors.

CHE 413 Heterogeneous Catalysis and Surface Characterization 3 Credits

History and concepts of heterogeneous catalysis. Surface characterization techniques, and atomic structure of surfaces and adsorbed monolayers. Kinetics of elementary steps (adsorption, desorption, and surface reaction) and overall reactions. Catalysis by metals, metal oxides, and sulfides. Industrial applications of catalysis: selective oxidation, pollution control, ammonia synthesis, hydrogenation of carbon monoxide to synthetic fuels and chemicals, polymerization, hydrotreating, and cracking.

CHE 415 Transport Processes 3 Credits

A combined study of the fundamentals of momentum transport, energy transport and mass transport and the analogies between them. Evaluation of transport coefficients for single and multicomponent systems. Analysis of transport phenomena through the equations of continuity, motion, and energy.
Prerequisites: CHE 461 or ENGR 452 or CHE 452

CHE 417 (BIOE 417, MAT 417) Soft Materials: Mechanics and Physics 3 Credits

Physical and mechanical behavior of soft materials such as gels, foams, rubbers, soft adhesives, and most biological tissue. Large strain kinematics, stress measures, constitutive relations from the molecular and continuum points of view, and application to problems such as cavitation, creasing, thin structures, fracture, adhesion, surface stress, and electroactive materials.
Prerequisites: CHE 452 or ENGR 452

CHE 418 (BIOE 418, MAT 418) Soft Materials: Rheology and Characterization 3 Credits

See the course description listed for CHE/BIOE/MAT 318. In order to receive 400-level credits, the student must do an additional, more advanced term project, as defined by the instructor at the beginning of the course. Closed to students who have taken CHE/BIOE/MAT 318.

CHE 421 (BIOE 421) Biomolecular & Cellular Mechanics 3 Credits

Mechanics and physics of cell components, from fundamental biomolecules to the entire cell. The mechanics of proteins and other biopolymers in 1D, 2D, and 3D structures, cell membrane structure and dynamics, and the mechanics of the whole cell. This course is a graduate version of CHE 321 (BioE/Phy 321). The lecture content will be the same as in CHE 321 (BioE/Phy 321), but students enrolled in CHE 421 (BIOE 421) will have more advanced assignments. Closed to students who have completed CHE 321 (BioE/Phy 321). Must have graduate standing or consent of instructor.

CHE 428 Rheology 3 Credits

An intensive study of momentum transfer in elastic viscous liquids. Rheological behavior of solution and bulk phase polymers with emphasis on the effect of molecular weight, molecular weight distribution and branching. Derivation of constitutive equations based on both molecular theories and continuum mechanics principles. Application of the momentum equation and selected constitutive equations to geometries associated with viscometric flows. Consent of instructor required.
Prerequisites: CHE 461 or CHE 452

CHE 430 Mass Transfer 3 Credits

Theory and developments of the basic diffusion and mass transfer equations and transfer coefficients including simultaneous heat and mass transfer, chemical reaction and dispersion effects. Applications to various industrially important operations including continuous contact mass transfer, absorption, humidification, etc. Brief coverage of equilibrium stage operations as applied to absorption and to binary and multicomponent distillation.

CHE 433 (ECE 433, ME 433) Linear Systems and Control 3 Credits

This course covers the following topics in linear systems and control theory: review of fundamental concepts in linear algebra, state-space representation of linear systems, linearization, time-variance and linearity properties of systems, impulse response, transfer functions and their state-space representations, solution to LTI and LTV state equations, Jordan form, Lyapunov stability, input-output stability, controllability, stabilizability, observability, detectability, Canonical forms, minimal realizations, introduction to optimal control theory, Linear Quadratic Regulator (LQR), Algebraic Riccati Equation (ARE), frequency domain properties of LQR controllers.
Prerequisites: CHE 386 or ME 343 or ECE 212

CHE 434 (ECE 434, ME 434) Multivariable Process Control 3 Credits

A state-of-the-art review of multivariable methods of interest to process control applications. Design techniques examined include loop interaction analysis, frequency domain methods (Inverse Nyquist Array, Characteristic Loci and Singular Value Decomposition) feed forward control, internal model control and dynamic matrix control. Special attention is placed on the interaction of process design and process control. Most of the above methods are used to compare the relative performance of intensive and extensive variable control structures.
Prerequisites: CHE 433 or ME 433 or ECE 433

CHE 436 (ECE 436, ME 436) Systems Identification 3 Credits

The determination of model parameters from time history and frequency response data by graphical, deterministic and stochastic methods. Examples and exercises taken from process industries, communications and aerospace testing. Regression, quasilinearization and invariant-imbedding techniques for nonlinear system parameter identification included.

CHE 438 Process Modeling and Control Seminar 1 Credit

Presentations and discussions on current methods, approaches, and applications. Credit cannot be used for the M.S. degree.

CHE 439 (BIOE 439) Neuronal Modeling and Computation 3 Credits

This course is a graduate version of CHE 339 (BIOE 339). While the lecture content will be the same as the 300-level course, students in the 400-level class will be expected to complete an independent term project. Closed to students who have completed CHE 339 (BIOE 339). Must have graduate standing in Chemical Engineering or Bioengineering.

CHE 440 Chemical Engineering in the Life Sciences 3 Credits

Introduction of important topics in life sciences to chemical engineers. Topics include protein and biomolecule structures and characterization, recombinant DNA technology, immunoaffinity technology, combinatorial chemistry, metabolic engineering, bioinformatics. Must have Bachelor’s degree in science or engineering.

CHE 441 (BIOE 441) Biotechnology I 3 Credits

See the course description listed for CHE 341 (BIOE 341). In order to receive 400-level credits, the student must do an additional, more advanced term project, as defined by the instructor at the beginning of the course. Closed to students who have taken CHE 341 (BIOE 341).

CHE 442 (BIOE 442) Biotechnology II 3 Credits

See the course description listed for CHE 342 (BIOE 342). In order to receive 400-level credits, the student must do an additional, more advanced term project, as defined by the instructor at the beginning of the course. Closed to students who have taken CHE 342 (BIOE 342).

CHE 444 Bioseparations 3 Credits

Separation techniques for biomolecule isolation and purification. Theory and problems of bioaffinity chromatography, electromigration processes, and aqueous two-phase polymer extraction systems. Engineering principles for scaling-up bioseparation processes. Consent of instructor required.

CHE 445 (BIOE 445) Quantitative Biology 3 Credits

This course is a graduate-level version of BIOE 345. While the lecture content will be the same as the 300-level course, students enrolled in BIOE 445 will have more advanced assignments. Closed to students who have taken BIOE 345.

CHE 446 Biochemical Engineering Laboratory 0,3 Credits

Laboratory and pilot-scale experiments in fermentation and enzyme technology, tissue culture, and separations techniques. Closed to students who have taken CHE 346.
Prerequisites: CHE 341 or CHE 444 or CHE 342
Can be taken Concurrently: CHE 342

CHE 447 (BIOE 447) Molecular Bioengineering 3 Credits

This course is a graduate version of CHE 344 (BIOE 344). While the lecture content will be the same as the 300-level course, students enrolled in CHE 444 will have more advanced assignments. Closed to students who have completed CHE 344 (BIOE 344).

CHE 448 Topics in Biochemical Engineering 3 Credits

Analysis, discussion, and review of current literature for a topical area of biotechnology. may be repeated for credit with the consent of the instructor. Consent of instructor required.
Repeat Status: Course may be repeated.

CHE 449 (BIOE 449) Metabolic Engineering 3 Credits

Quantitative perspective of cellular metabolism and biochemical pathways. Methods for analyzing stoichiometric and kinetic models, mass balances, flux in reaction networks, and metabolic control. Solving problems using advanced mathematics and computer programming. Closed to students who have completed BIOE 349. Must have graduate standing in Chemical Engineering or Bioengineering.

CHE 450 Special Topics 1-12 Credits

An intensive study of some field of chemical engineering not covered in the more general courses. Credit above three hours is granted only when different material is covered.

CHE 451 Problems In Research 1 Credit

Study and discussion of optimal planning of experiments and analysis of experimental data. Discussion of more common and more difficult techniques in the execution of chemical engineering research.

CHE 452 (BIOE 452, ENGR 452, ME 452) Mathematical Methods In Engineering I 3 Credits

Analytical techniques relevant to the engineering sciences are described. Vector spaces; eigenvalues; eigenvectors. Linear ordinary differential equations; diagonalizable and non- diagonalizable systems. Inhomogeneous linear systems; variation of parameters. Non-linear systems; stability; phase plane. Series solutions of linear ordinary differential equations; special functions. Laplace and Fourier transforms; application to partial differential equations and integral equations. Sturm-Liouville theory. Finite Fourier transforms; planar, cylindrical, and spherical geometries.

CHE 453 Teaching Apprentice 1 Credit

Students will work under the guidance of individual Faculty instructors to participate in some of the following teaching tasks: Development of the course syllabus, preparation and grading of homework and exams, holding a recitation and/or lecture section. Must have graduate standing in ChE department.
Repeat Status: Course may be repeated.

CHE 454 Seminar 0-3 Credits

Critical discussion of recent advances in chemical engineering.

CHE 455 Seminar 1-3 Credits

Critical discussion of recent advances in chemical engineering. Credit above one hour is granted only when different material is covered.

CHE 456 (BIOE 456) Stochastic Processes: Theory and Applications in Biology 3 Credits

Stochastic, or probabilistic, models of cellular processes and other biological systems to describe the inherent randomness of nature. Topics covered include theory and biological applications of Markov chains, the Master Equation, white noise and stochastic integrals, the Fokker-Planck Equation, and noise in gene expression. Some minimal experience in programming and/or Mathematica/Matlab.
Prerequisites: MATH 205

CHE 460 Chemical Engineering Project 1-6 Credits

An intensive study of one or more areas of chemical engineering, with emphasis on engineering design and applications. A written report is required.
Repeat Status: Course may be repeated.

CHE 463 (BIOE 463) Numerical Methods for Scientists and Engineers 3 Credits

See the course description listed for CHE 363 (BIOE 363). This course is graduate version of CHE 363 (BIOE 363). The lecture content will be the same as CHE 363 (BIOE 363), but students enrolled in CHE 463 (BIOE 463) will have more advanced assignments. Closed to students who have taken CHE 363 (BIOE 363). Must have graduate standing or consent of the instructor.

CHE 465 Molecular Modeling and Simulation 3 Credits

See the course description listed for CHE 365. This course is graduate version of CHE 365. The lecture content will be the same as CHE 365, but students enrolled in CHE 465 will have more advanced assignments. Closed to students who have taken CHE 365. Must have graduate standing or consent of the instructor.

CHE 467 (BIOE 467) Engineering in Medicine 3 Credits

See the course description listed for CHE 367 (BIOE 367). In order to receive 400-level credits, the student must do an additional, more advanced term project, as defined by the instructor at the beginning of the course. Closed to students who have taken CHE 367 (BIOE 367), or BIOE 467.

CHE 469 (BIOE 469) Advanced Topics in Regulatory Affairs 3 Credits

This course is a graduate version of BIOE 369 (CHE 369). While the lecture content will be the same as the 300-level course, students enrolled in BIOE 469 (CHE 469) will have more advanced assignments. Closed to students who have taken BIOE/CHE 369.

CHE 473 Environmental Separation and Control 3 Credits

Theory and application of adsorption, ion exchange, reverse osmosis, air stripping and chemical oxidation in water and wastewater treatment. Modeling engineered treatment processes.
Prerequisites: CEE 470

CHE 480 Research 3 Credits

Investigation of a problem in chemical engineering.

CHE 481 Research 3 Credits

Continuation of CHE 480.

CHE 482 (CHM 482, MAT 482) Mechanical Behaviors of Polymers 3 Credits

Mechanical behavior of polymers. Characterization of viscoelastic response with the aid of mechanical model analogs. Time-temperature superposition, experimental characterization of large deformation, and fracture processes, polymer adhesion. Effects of fillers, plasticizers, moisture, and aging on mechanical behavior.

CHE 483 (CHM 483, MAT 483) Emulsion Polymers 3 Credits

Examination of fundamental concepts important in the manufacture, characterization, and application of polymer latexes. Topics to be covered will include colloidal stability, polymerization mechanisms and kinetics, reactor design, characterization of particle surfaces, latex rheology, morphology considerations, polymerization with functional groups, film formation and various application problems.

CHE 485 (CHM 485, MAT 485) Polymer Blends 3 Credits

Synthesis, morphology, and mechanical behavior of polymer blends. Polymer/polymer miscibility and thermodynamics of mixing of polymer/solvent and polymer/polymer blends. Prediction of miscibility using various theoretical models and methods that can be used to help enhance miscibility (H bonding etc.). Methods to enhance the compatibility of polymer/polymer blends (e.g., block copolymers, ternary addition, IPNs), etc.). Types of polymer blends. Must have completed any introductory polymer course or equivalent.

CHE 486 Polymer Processing 3 Credits

Application of fundamental principles of mechanics, fluid dynamics and heat transfer to the analysis of a wide variety of polymer flow processes. A brief survey of the rheological behavior of polymers is also included. Topics include pressurization, pumping, die forming, calendering, coating, molding, fiber spinning and elastic phenomena.

CHE 490 Thesis 1-6 Credits

CHE 492 (CHM 492, MAT 492) Topics in Polymer Science 3 Credits

Intensive study of topic selected from areas of current research interest such as morphology and mechanical behavior, thermodynamics and kinetics of crystallization, new analytical techniques, molecular weight distribution, non-Newtonian flow behavior, second order transition phenomena, novel polymer structures. Credit above three hours is granted only when different material is covered.
Prerequisites: CHE 392 or CHE 392 or CHM 392 or CHM 392

CHE 499 Dissertation 1-15 Credits

Repeat Status: Course may be repeated.