2022-23 Catalog

Children's Environmental Precision Institute (CEPH)

CONTACT

Director: Hyunok Choi, PhD, MPH
Email: hyc219@lehigh.edu
Phone: 610.758.2626
Website: health.lehigh.edu/research-partnerships/childrens-environmental-precision-health-institute

Affiliated Faculty

  • Karen Beck-Pooley, PhDProfessor of Practice, Political Science, Lehigh University
  • Aimin Chen, MD, PhDProfessor of Epidemiology, Perelman School of Medicine, University of Pennsylvania
  • Hyunok Choi, PhD, MPHAssociate Professor and Director, Children’s Environmental Precision Health Institute
  • Lifang He, PhDComputer Science & Engineering, Assistant Professor, Lehigh University
  • Suk-Mei Ho, PhDVice-Provost for Research and Professor, University of Arkansas
  • Breena Holland, PhDPolitical Science, Associate Professor, Lehigh University
  • Jeremy Mack, MSGeospacial Data Visualization Specialist, LTS, Lehigh University
  • John Spengler, PhDAkira Yamaguchi Professor of Environmental Health and Human Habitation, Harvard T. H. Chan School of Public Health
  • Dimitrios Vavylonis, PhD, Professor, Department of Physics, Lehigh University
  • Fathima Wakeel, PhD, MPHAssociate Professor and Director of Graduate Programs
  • Muzhe Yang, PhD, Professor, Department of Economics, Lehigh University
  • Bin Zhang, PhDProfessor of Genetics and Genomic Sciences and Pharmacological Sciences, Mount Sinai School of Medicine

OVERVIEW

Does cancer begin when you are growing in the womb?  How do your inherent susceptibility factors (e.g., genome, adductome, and transcriptome) interact with environmental exposures (e.g., airborne toxics) as well as physical home indoor, neighborhood, school conditions to increase your risk of asthma, allergies, and obesity?  Are you more susceptible to such diseases if exposed to environmental toxics as a fetus or an infant?  These are some of the questions Children’s Environmental Precision Health (CEPH) Institute aims to answer.  A better understanding will help us detect, intervene, and prevent high-risk infants and toddlers from developing irreversible impairment to reaching their physical and intellectual potential.

Research

The Institute’s mission is to improve children’s health and well-being through the following research, education, and service activities: 

  • Early-life origins of obesity-associated asthma sub-species: To date, it remains unknown how many actual diseases reside within the umbrella term, asthma. Identifying distinct subspecies of asthma is important because only one treatment strategy exists worldwide. One of the main goals of our ongoing investigations is to speciate asthma into concrete disease entities characterized in terms of underlying mechanistic processes. Successful speciation is expected to yield more precise and effective intervention approaches. 
  • Sexual dimorphism: Another critical goal of the CEPH investigators is to understand why males and females differ in their vulnerability to environmental pollutants. 
  • Environmental justice within Pennsylvania: To date, the community-level disparity in environmental pollutant exposures is often ignored in determining the justice needs and goals. Projects within CEPH aim to propose a novel definition of Pennsylvania’s environmental justice target regions in terms of disparity in health outcomes, pollution exposures, and socioeconomic indicators.

Education

CEPH has three educational missions and goals:

  • Train students in environmental health science research: CEPH aims to provide students with opportunities to participate in existing research programs.
  • Cultivate confidence:  The projects in CEPH are designed to engage students as independent investigators rather than mere observers and apprentices. Starting from the first year of engagement, the students are encouraged to publish and present their findings at national research conferences. 
  • Collaborate through team science:  Working well within a team of peers represents an essential experience for the students. The students are expected to benefit from mutual mentoring and collective problem solving as multi-disciplinary team members.  

Service

CEPH will engage with community members to develop individual- and community-level strategies to reduce exposures to harmful environmental pollutants and prevent the risks.  Student-led community-oriented engagement projects will be created and supervised. Two service goals are as follows:

  • Learn from the community members: Focus on better understanding the barriers to prevention and management through deep engagement with the Lehigh Valley community members.
  • Deepen the partnership: The CEPH will also organize free information-sharing sessions for Lehigh Valley community families.

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