2017-18 Catalog

Bioengineering

The mission of the Bioengineering Department is to prepare undergraduate students to be critical thinkers, problem solvers, innovators, leaders, and lifelong learners who can make a positive impact at the interfaces among the physical and life sciences, and engineering.

To achieve its educational mission, the Bioengineering Department has established the following set of Degree Educational Objectives. Three to five years after graduation, we expect that

1. Graduates in professional practice function effectively as responsible and collaborative professionals in Bioengineering or in a related field.

2. Graduates pursue advanced degrees or engage in other forms of continuing education.

Bioengineering Faculty

Professor Anand Jagota, Director, Department of Chemical Engineering at 610-758-4396 or anj6@lehigh.edu

Professor of Practice Lori Herz, Associate Director, Department of Chemical Engineering at 610-758-6831 or loh208@lehigh.edu

Core Program Faculty: Yevgengy Berdichevsky, Ph.D. (UC San Diego) Electrical and Computer Engineering; Bryan Berger, Ph.D. (Delaware) Chemical Engineering; Javier Buceta, Ph.D. (Universidad Nacional de Educacion a Distancia, Spain)  Chemical Engineering; Xuanhong Cheng, Ph.D. (U. of Washington) Materials Science and Engineering; Lesley Chow, Ph.D. (Northwestern) Materials Science and Engineering; James T. Hsu, Ph.D. (Northwestern) Chemical Engineering; Anand Jagota, Ph.D. (Cornell) Chemical Engineering; Sabrina Jedlicka Ph.D. (Purdue) Materials Science and Engineering; Linda Lowe-Krentz, Ph.D. (Northwestern) Biological Sciences; Yaling Liu, Ph.D. (Northwestern) Mechanical Engineering and Mechanics; H. Daniel Ou-Yang, Ph.D. (UCLA) Physics; Svetlana Tatic-Lucic, Ph.D. (California Institute of Technology) Electrical and Computer Engineering; Arkady S. Voloshin, Ph.D. (Tel Aviv University, Israel), Mechanical Engineering and Mechanics; Xaiohui Zhang, Ph.D. (Miami) Mechanical Engineering and Mechanics; Chao Zhou, Ph.D. (Pennsylvania) Electrical and Computer Engineering.

Professor of Practice: Lori E. Herz, Ph.D. (Rutgers) Chemical Engineering;  Susan F. Perry, Ph.D. (Pennsylvania State University) Biological Chemistry.

Undergraduate Program

The B.S. in Bioengineering degree provides a structured curriculum comprised of three tracks. Biopharmaceutical Engineering is for students whose interests lie in genomics, proteomics, bioinformatics, recombinant DNA, protein engineering, bioprocessing, drug synthesis and delivery. The Bioelectronics/photonics track covers education and research dealing with signal processing, biosensors, MEMs, biochips for DNA sequencing, laser and fiber based optical technology for biomedical applications. The Biomechanics and Biomaterials track encompasses applications of engineering principles to an understanding of biology and physiology, ranging from cells and tissues to organs and systems.

The B.S. in Bioengineering will prepare students for careers in established and emerging fields that require combining engineering principles with the life sciences. Potential paths open to students include the health care, biomedical, pharmaceutical, biomaterials, and other biotechnology related industries through careers in medicine or graduate studies.

The program strongly encourages experiential learning, including two summers of internships, required participation in Lehigh's Technical Entrepreneurship Capstone Design Projects, and opportunities for undergraduate research for credit.

A total of 132 credit hours are required for graduation with a degree of bachelor of science in bioengineering.

Bioengineering Core Requirements

General Requirements
ENGL 001Critical Reading and Composition3
ENGL 002Research and Argument3
ECO 001Principles of Economics4
BIOE 226Ethics in Bioengineering Practice1
or PHIL 116 Bioethics
or PHIL 105 Ethics
ENGR 010Applied Engineering Computer Methods2
Electives to satisfy HSS depth and breadth requirements13
Free Electives (Number of general requirements and free elective credits are track-dependent.)3-5
Mathematics
MATH 021Calculus I4
MATH 022Calculus II4
MATH 023Calculus III4
MATH 205Linear Methods 13
MATH 231Probability and Statistics 13
Chemistry
CHM 030Introduction to Chemical Principles4
CHM 031Chemical Equilibria in Aqueous Systems4
CHM 110
CHM 111
Organic Chemistry I
and Organic Chemistry Laboratory I
4
Physics
PHY 011
PHY 012
Introductory Physics I
and Introductory Physics Laboratory I
5
PHY 021
PHY 022
Introductory Physics II
and Introductory Physics Laboratory II
5
Biological Sciences
BIOS 041
BIOS 042
Biology Core I: Cellular and Molecular
and Biology Core I: Cellular and Molecular Lab
4
BIOS 115
BIOS 116
Biology Core II: Genetics
and Biology Core II: Genetics Laboratory
4
Integrated Bioengineering
Required by all Three Tracks
BIOE 001Freshman Seminar 1, Introduction to Bioengineering 1: Philosophy to Practice (Pass/Fail)1
BIOE 002Freshman Seminar 2, Introduction to Bioengineering II: Current Topics (Pass/Fail)1
BIOE 110Elements of Bioengineering4
BIOE 210Introduction to Engineering Physiology4
TE 211Capstone Design Projects-13
TE 212Capstone Design Projects-22
BIOE 225GMP Good manufacturing practice and regulatory affairs for bioengineers1
Engineering Requirement by Track
Select one of the following tracks:22-24
Biopharmaceutical Engineering Track
Organic Chemistry II
Integrated Biotechnology Laboratory
Engineering Materials and Processes
Material and Energy Balances of Chemical Processes
Chemical Engineering Thermodynamics
Chemical Reactor Design 2
Biological Fluid Mechanics
Bioelectronic/Biophotonics Track
Signals and Systems
Integrated Bioelectronics/Biophotonics Laboratory
Principles of Electrical Engineering
Electronic Circuits Laboratory
Electronic Circuits
Introduction to Electromagnetics
Fundamentals of Engineering Mechanics
Engineering Materials and Processes
Biomechanics and Biomaterials Track
Fundamentals of Engineering Mechanics
Strength of Materials
Engineering Materials and Processes
Thermodynamics of Macro/Nanoscale Materials
Thermodynamics I
Biomechanics and Biomaterials
Integrated Biostructural Mechanics Laboratory
Biological Fluid Mechanics
Bioengineering Electives
Select one of the following:3
Bioengineering Statistics
Biotechnology I 3
Biomolecular & Cellular Mechanics
Metabolic Engineering
Quantitative Biology
Introduction to Micro- and Nanofabrication
Technical Electives 49
Total Credits127-131
1

Students must achieve a minimum of a C- in both MATH 205 and MATH 231 for the B.S. in Bioengineering.

2

Note: BIOE 349 (Metabolic Engineering) may be taken in lieu of CHE 211. If BIOE 349 is taken instead of CHE 211, it may not count as an elective.

3

Students in the Biopharmaceutical Engineering track are required to take BIOE 341, since it is a prerequisite for BIOE 343.

4

Students must take nine (9) credits of technical electives, which include undergraduate research, graphics for engineering design, engineering courses at the 200-level or higher, and BIOS/CHM/PHY/MATH courses at the 200-level or higher. (Some 200-level courses are excluded from this list; the complete list of approved courses is available from the Bioengineering Program or the Registrar.) At least three (3) of the nine (9) credits must be a BIOE class at the 300-level or higher. No more than six (6) credits can be from CSE 002, CSE 017ME 010, BIOE 020, BIOE 132, BIOE 142, BIOE 242, and BIOE 290.

Typical four-year course schedule for BS in Bioengineering

Biopharmaceutical Engineering Track

First Year
First SemesterCreditsSecond SemesterCredits
BIOE 001 (Pass/Fail)1BIOE 002 (Pass/Fail)1
CHM 0304BIOS 041
BIOS 042
4
MATH 0214MATH 0224
ENGL 0013PHY 011
PHY 012
5
ENGR 0102ENGL 0023
 14 17
Second Year
First SemesterCreditsSecond SemesterCredits
BIOE 1104BIOE 2104
MATH 0234BIOE 0201
PHY 021
PHY 022
5CHM 0314
CHE 0313MATH 2053
 CHE 2104
 16 16
Third Year
First SemesterCreditsSecond SemesterCredits
CHM 110
CHM 111
4TE 2113
BIOS 115
BIOS 116
4CHE 2113
BIOE 3413BIOE 2474
BIOE 2251CHM 1123
MATH 2313ECO 0014
Elective3 
 18 17
Fourth Year
First SemesterCreditsSecond SemesterCredits
TE 2122Electives16
BIOE 3433BIOE 2261
MAT 0333 
Electives9 
 17 17
Total Credits: 132

Bioelectronics/Biophotonics Track

First Year
First SemesterCreditsSecond SemesterCredits
BIOE 001 (Pass/Fail)1BIOE 002 (Pass/Fail)1
CHM 0304BIOS 041
BIOS 042
4
MATH 0214MATH 0224
ENGL 0013PHY 011
PHY 012
5
ENGR 0102ENGL 0023
 14 17
Second Year
First SemesterCreditsSecond SemesterCredits
BIOE 1104BIOE 2104
MATH 0234BIOE 0201
ECE 0814MATH 2053
PHY 021
PHY 022
5CHM 0314
 ECE 123
ECE 121
5
 17 17
Third Year
First SemesterCreditsSecond SemesterCredits
BIOS 115
BIOS 116
4MATH 2313
CHM 110
CHM 111
4TE 2113
MAT 0333BIOE 3312
ECE 1084MECH 0033
BIOE 2251ECO 0014
 Elective3
 16 18
Fourth Year
First SemesterCreditsSecond SemesterCredits
TE 2122Electives16
ECE 202 or PHY 2123BIOE 2261
Electives12 
 17 17
Total Credits: 133

Biomechanics and Biomaterials Track

First Year
First SemesterCreditsSecond SemesterCredits
BIOE 001 (Pass/Fail)1BIOE 002 (Pass/Fail)1
CHM 0304BIOS 041
BIOS 042
4
MATH 0214MATH 0224
ENGL 0013PHY 011
PHY 012
5
ENGR 0102ENGL 0023
 14 17
Second Year
First SemesterCreditsSecond SemesterCredits
BIOE 1104BIOE 2104
MECH 0033BIOE 0201
MATH 0234MATH 2053
PHY 021
PHY 022
5CHM 0314
 MAT 0333
 MAT 2053
 16 18
Third Year
First SemesterCreditsSecond SemesterCredits
CHM 110
CHM 111
4TE 2113
MATH 2313BIOE 2573
BIOS 115
BIOS 116
4BIOE 3572
Electives6BIOE 2474
BIOE 2251Electives3
 MECH 0123
 18 18
Fourth Year
First SemesterCreditsSecond SemesterCredits
TE 2122Electives16
ECO 0014BIOE 2261
Electives12 
 18 17
Total Credits: 136

Graduate Program

Bioengineering offers a graduate program leading to the doctor of philosophy degree. The graduate program will train students to solve problems that require the application of interdisciplinary knowledge, combining life sciences, physical sciences, and engineering. The program will emphasize cellular and biomolecular science and engineering, and aims to attract students with diverse academic backgrounds. Students who do not complete the doctor of philosophy have the option to earn a master of science.

Major Requirements

Doctor of Philosophy Degree

Candidates for the doctor of philosophy degree are required to complete a minimum of 72 credits.

ENGR 452Mathematical Methods in Engineering3
BIOS 411Advanced Cell Biology3
Two additional core courses from an approved list of courses6
Twelve credits of adviser-approved technical electives at the 300-level or higher12
Six credits of dissertation research6
Additional 42 credits of electives and/or dissertation research 42
Total Credits72

 Students must pass a qualification exam, typically taken after three semesters of study,  a final written dissertation as well as an oral defense of the dissertation.

Master of Science Degree

An oral defense of thesis research is dependent upon the requirements of the student's adviser.

Two options for the master of science degree are available: a thesis option and a non-thesis option. Candidates for both the thesis and non-thesis master of science degree are required to complete a minimum of 30 credits.  Per university policy, graduate students may count no more than 12 credits at the 300-level toward the M.S. degree.

Thesis Option

ENGR 452Mathematical Methods in Engineering3
BIOS 411Advanced Cell Biology3
Two additional core courses from an approved list of courses6
Twelve credits of adviser-approved technical electives at the 300-level or higher.12
Six credits of thesis research, culminating in a written thesis. 6
Total Credits30

Non-Thesis Option

ENGR 452Mathematical Methods in Engineering3
BIOS 411Advanced Cell Biology3
Two additional core courses from an approved list of courses6
Eighteen credits of adviser-approved technical electives at the 300-level or higher. No thesis research or written thesis is required.18
Total Credits30

Courses

BIOE 001 Freshman Seminar 1, Introduction to Bioengineering 1: Philosophy to Practice 1 Credit

Overview of the bioengineering field, the advancements of related topics in sciences, technology, engineering and applications for health care and medicine. Humanity and ethical issues. Pass/Fail.

BIOE 002 Freshman Seminar 2, Introduction to Bioengineering II: Current Topics 1 Credit

Overview of a broad spectrum of current topical areas in biotechnology and bioengineering and their applications in health care and medicine. Pass/Fail.

BIOE 020 Bioengineering Sophomore Research Seminar 1 Credit

Exposure to opportunities for on-campus research in bioengineering. Review of current literature on bioengineering topics through written reports and/or oral presentations. Preparation of written research proposal, including definition of topic, objectives, methodologies, research plans, and expected impact.

BIOE 110 Elements of Bioengineering 4 Credits

An introduction to the fields of biotechnology and biomedical engineering. The areas include biomechanics, biomaterials, bioinstrumentation, medical imaging, rehabilitation engineering, biosensors, biotechnology and tissue engineering.
Prerequisites: (BIOS 041 and BIOS 042)

BIOE 210 Introduction to Engineering Physiology 4 Credits

Mammalian physiology for bioengineering students, with an emphasis on control mechanisms and engineering principles. Basic cell function; biological control systems; muscle; neural; endocrine, circulatory, digestive, respiratory, renal, and reproductive systems; regulation of metabolism and defense mechanisms. Includes laboratory work.
Prerequisites: (BIOS 041 and BIOS 042) and (BIOE 110)

BIOE 225 GMP Good manufacturing practice and regulatory affairs for bioengineers 1 Credit

Review of the principles of the Food and Drug Administration including its history, mission and applied regulations. Understanding of how the FDA works with industry and is integral to the development of new products and technologies. Review and critique of case studies in various parts of the biomedical industry to see how FDA regulations are applied. Validation and analysis of products using failure mode analysis.
Prerequisites: BIOE 110

BIOE 226 Ethics in Bioengineering Practice 1 Credit

Introduction to ethical principles and role of critical thinking in ethical decision-making. Analysis of contemporary issues in bioengineering practice. Topics include biomedical device risk and failure, ethics of clinical trials, animal research, human enhancement, and research conduct.

BIOE 242 Bioengineering Research 1-4 Credits

Research on a topic chosen by students, with a faculty advisor typically from the three bioengineering tracks (biopharmaceutical engineering, bioelectronic/biophotonics or biomechanics and biomaterials). Independent meetings with advising professor will track progress. Includes written reports and/or oral presentations. Consent of instructor required.
Repeat Status: Course may be repeated.

BIOE 247 Biological Fluid Mechanics 4 Credits

Fluid and mass transport and their applications in biological systems. Mass conservation. Momentum and energy balances in fluid flow. Incompressible fluid flow with inviscid and viscous applications. Dimensional analysis. Fluid flow in pipes and porous media. Diffusion and convection.
Prerequisites: MATH 205

BIOE 257 Biomechanics and Biomaterials 3 Credits

Biomechanical analysis of tissues, microstructure of materials, force and mechanics in rigid and deformable bodies, analysis of biological response and biocompatibility, failure processes of implantable biomaterials/devices, strength of materials, and biomechanics of cells. Biomechanics and biomaterials concepts integrated (1) to examine the theoretical and practical implications of material properties and (2) to examine the biomechanical principles governing system behavior.
Prerequisites: MAT 033 and MECH 003 and MATH 205
Can be taken Concurrently: MATH 205

BIOE 290 Bioengineering Thesis 1-3 Credits

Thesis, guided by a faculty advisor, based on research and/or design projects. Independent meetings with advising professor to track progress. Consent of instructor required.
Prerequisites: BIOE 242 or TE 212

BIOE 307 (CSE 307) 3 Credits

Computational techniques and principles of structural biology used to examine molecular structure, function, and evolution. Topics include: protein structure alignment and prediction; molecular surface analysis; statistical modeling; QSAR; computational drug design; influences on binding specificity; protein-ligand, -protein, and -DNA interactions; molecular simulation, electrostatics. Tutorials on UNIX systems and research software support an interdisciplinary collaborative project in computational structural biology. Credit will not be given for both CSE 307 and CSE 407. Must have junior standing or higher.
Prerequisites: BIOS 120 or CSE 109 or CHM 113 or MATH 231

BIOE 308 (CSE 308) Bioinformatics: Issues and Algorithms 3 Credits

Computational problems and their associated algorithms arising from the creation, analysis, and management of bioinformatics data. Genetic sequence comparison and alignment, physical mapping, genome sequencing and assembly, clustering of DNA microarray results in gene expression studies, computation of genomic rearrangements and evolutionary trees. Credit will not be given for both BIOE 308 (CSE 308) and BIOE 408 (CSE 408). No prior background in biology is assumed.
Prerequisites: CSE 017 or CSE 018
Attribute/Distribution: ND

BIOE 315 (ME 315) Bioengineering Statistics 3 Credits

Advanced methods in probability and statistics applied to bioengineering problems focusing on modeling and data analysis. Topics include the following: types of data, types of distributions, parametric and nonparametric analyses, goodness-of-fit, regression, power analysis, and multivariate analysis, life models, simulation, cluster analysis, and Bayesian statistics. Special emphasis is placed on projects and case studies.
Prerequisites: MATH 231

BIOE 320 (CSE 320) Biomedical Image Computing and Modeling 3 Credits

Biomedical image modalities, image computing techniques, and imaging informatics systems. Understanding, using, and developing algorithms and software to analyze biomedical image data and extract useful quantitative information: Biomedical image modalities and formats; image processing and analysis; geometric and statistical modeling; image informatics systems in biomedicine. Credit will not be given for both BioE 320 and BioE 420.
Prerequisites: (MATH 205 or MATH 043) and CSE 017
Attribute/Distribution: ND

BIOE 321 (PHY 321) Biomolecular & Cellular Mechanics 3 Credits

Mechanics and physics of the components of the cell, ranging in length scale from fundamental biomolecules to the entire cell. The course covers the mechanics of proteins and other biopolymers in 1D, 2D, and 3D structures, cell membrane structure and dynamics, and the mechanics of the whole cell.
Prerequisites: MATH 205 and MATH 231 and PHY 022 and (PHY 013 or PHY 021 or PHY 023)
Attribute/Distribution: NS

BIOE 324 (MAT 324) Introduction to Organic Biomaterials 3 Credits

Property, characterization, fabrication and modification of organic materials for biomedical and biological applications; host responses to biomaterials on the molecular, cellular and system level; general introduction to biosensors, drug delivery devices and tissue engineering.
Prerequisites: BIOE 110

BIOE 325 (MAT 325) Inorganic Biomaterials 3 Credits

Fabrication methods for biomedical implants and devices. Selection of metals and ceramics with specific bulk and surface physical as well as chemical properties. The role of materials chemistry and microstructure. Biocompatibility. Case studies (dental and orthopedic implants, stents, nonporous ceramic filters for kidney dialysis).
Prerequisites: MAT 033

BIOE 326 (MAT 326) Biomimetic and Bio-enabled Materials 3 Credits

The structure, function, properties and use of biopolymers, biocomposites, and biominerals. Biomimetic materials design, including colloids, interfaces, macromolecules, and applications of such materials. Environmental and ethical considerations, such as degradation products when using biomimetic materials. Closed to students who have taken MAT 426 (BioE 426).
Prerequisites: MAT 033 or BIOE 110
Attribute/Distribution: ND

BIOE 331 (PHY 331) Integrated Bioelectronics/Biophotonics Laboratory 2 Credits

Experiments in design and analysis of bioelectronics circuits, micropattering of biological cells, micromanipulation of biological cells using electric fields, analysis of pacemakers, instrumentation and computer interfaces, ultrasound, optic, laser tweezers and advanced imaging and optical microscopy techniques for biological applications.
Prerequisites: (ECE 081 or PHY 190) and (PHY 013 or PHY 021 or PHY 023) and PHY 022 and ECE 121 and ECE 123
Can be taken Concurrently: ECE 121, ECE 123
Attribute/Distribution: NS

BIOE 335 BioFluid Mechanics of Physiological Systems 3 Credits

Application of advanced fluid dynamic principles to physiological systems with emphasis on micron sized structures such as pulmonary airway/alveoli, small blood vessels and biological cells. Introduction to advanced topics relevant to the human body including a) oscillatory and transient flows in the cardiovascular and pulmonary systems b) non-Newtonian flows, c) surface tension driven flows, d) fluid-structure interactions, and e) cellular fluid mechanics.
Prerequisites: (MATH 205 and ME 231 and MATH 231)

BIOE 339 Neuronal Modeling and Computation 3 Credits

Neuroscience in a computational, mathematical, and engineering framework. Literature surveys and case studies with simulations. Computational aspects of information processing within the nervous system by focusing on single neuron modeling. Single neurons and how their biological properties relate to neuronal coding. Biophysics of single neurons, signal detection and signal reconstruction, information theory, population coding and temporal coding.
Prerequisites: ENGR 010 and MATH 205

BIOE 341 (CHE 341) Biotechnology I 3 Credits

Applications of material and energy balances; heat, mass, and momentum transfer; enzyme and microbial kinetics; and mathematical modeling to the engineering design and scale up of bioreactor systems. Closed to students who have taken BioE 441 (CHE 441).
Prerequisites: (MATH 205 and CHE 031 and CHM 031)

BIOE 342 (CHE 342) Biotechnology II 3 Credits

Engineering design and analysis of the unit operations used in the recovery and purification of products manufactured by the biotechnology industries. Requirements for product finishing and waste handling will be addressed. Consent of instructor required. Closed to students who have taken BIOE 442 (CHE 442).
Prerequisites: CHE 031 and CHM 031

BIOE 343 Integrated Biotechnology Laboratory 3 Credits

Biosafety, sterilization, media formulation, biochemical and enzyme assays, recombinant DNA technique, protein and DNA isolation and purification, for microbial fermentation and animal cell culture. Integration of biotechnology techniques for biopharmaceutical production. Consent of instructor required.
Prerequisites: BIOE 110 and (CHE 341 or BIOE 341)

BIOE 344 (CHE 344) Molecular Bioengineering 3 Credits

Kinetics in small systems, stochastic simulation of biochemical processes, receptor-mediated adhesion, dynamics of ion-channels, ligand binding, biochemical transport, surface Plasmon resonance, DNA microarray design, and chemical approaches to systems biology. Senior standing in BIOE.
Prerequisites: (MATH 205 and MATH 231)

BIOE 345 (CHE 345) Quantitative Biology 3 Credits

Basic concepts in molecular and cellular biology as well as biochemistry. Connects these to engineering principles in order to (1) develop a quantitative understanding of biological systems and (2) understand how applications of methods and principles in biology are used in modern engineering. Topics include protein structure and function, enzymology, membrane transport and trafficking, transcription/translation, signal transduction and models for cellular processes. An important part of this course is also taking topics discussed in lecture and translating them into practice.
Prerequisites: MATH 205

BIOE 349 Metabolic Engineering 3 Credits

Quantitative perspective of cellular metabolism and biochemical pathways. Methods for analyzing stoichiometric and kinetic models, mass balances, flux in reaction networks, and metabolic control. Solving problems using advanced mathematics and computer programming.
Prerequisites: MATH 205 and MATH 231

BIOE 350 Special Topics 1-4 Credits

Special topics of study in bioengineering. Permission of Instructor.
Repeat Status: Course may be repeated.

BIOE 357 Integrated Biostructural Mechanics Laboratory 2 Credits

Experimental manipulation and analysis of mammalian cells, with a focus on the biomechanical properties of cells, the interface of living and non-living materials, and on bioengineering applications. Experimental techniques include mammalian cell culture, advanced microscopy techniques, preparation of bioactive substrates, microfluidic device fabrication, micropatterning of cells and cell growth in 3D matrices. Consent of instructor required.
Prerequisites: BIOE 110

BIOE 358 Biomechanics 3 Credits

Applications of mechanics to study behavior of anatomical structures and biological tissues of the musculoskeletal system. Specific topics include structure and function of biological tissues, mechanical properties of biological tissues, and analysis of specific tissues (i.e. bone, muscle, and soft connective tissues).
Prerequisites: MECH 003
Can be taken Concurrently: MECH 003

BIOE 359 Biomechanics Laboratory 1 Credit

Applications of mechanics to study behavior of anatomical structures and biological tissues of the musculoskeletal system. Specific topics include structure and function of biological tissues, mechanical properties of biological tissues, and analysis of specific tissues (i.e. bone, muscle, and soft connective tissues).
Prerequisites: MECH 003 and BIOE 358
Can be taken Concurrently: MECH 003, BIOE 358

BIOE 366 (ECE 366) Neural Engineering 3 Credits

Neural system interfaces for scientific and health applications. Basic properties of neurons, signal detection and stimulation, instrumentation and microfabricated electrode arrays. Fundamentals of peripheral and central neural signals and EEG, and applications such as neural prostheses, implants and brain-computer interfaces. Closed to students who have taken BIOE 466, ECE 366, or ECE 466.
Prerequisites: ECE 081

BIOE 368 (ECE 368) Introduction to Biophotonics and Optical Biomedical Imaging 3 Credits

Optical principles, techniques, and instruments used in biomedical research and clinical medicine. Fundamental concepts of optical imaging and spectroscopy systems, and details of light-tissue interaction. Commercial devices and instruments, as well as novel optical imaging technologies in development. Closed to students who have taken BIOE 468, ECE 368, or ECE 468.
Prerequisites: ECE 202 or PHY 212

BIOE 380 (BIOS 380) Biomolecular & Cellular Biophysics 3-4 Credits

Physical principles of biomolecular and cellular organization. Biomolecular interactions and recognition, molecular motors, physical organization and functioning of cellular membranes, electrical signaling in live cells. Modern techniques in biophysics, molecular spectroscopy, molecular modeling, florescence imaging, electrophysiology, electron microscopy.
Prerequisites: (BIOS 115) and (PHY 013 or PHY 021)

BIOE 407 (CSE 407) 3 Credits

Computational techniques and principles of structural biology used to examine molecular structure, function, and evolution. Topics include: protein structure alignment and prediction; molecular surface analysis; statistical modeling; QSAR; computational drug design; influences on binding specificity; protein-ligand, -protein, and –DNA interactions; molecular simulation, electrostatics. This course, a version of 307 for graduate students, requires advanced assignments and a collaborative project. Credit will not be given for both BIOE 307 and 407. Consent of instructor required.

BIOE 408 (CSE 408) Bioinformatics: Issues and Algorithms 3 Credits

Computational problems and their associated algorithms arising from the creation, analysis, and management of bioinformatics data. Genetic sequence comparison and alignment, physical mapping, genome sequencing and assembly, clustering of DNA microarray results in gene expression studies, computation of genomic rearrangements and evolutionary trees. This course, a version of 308 for graduate students requires advanced assignments. Credit will not be given for both BIOE 308 (CSE 308) and BIOE 408 (CSE 408). No prior background in biology is assumed.
Prerequisites: CSE 017 or CSE 018
Attribute/Distribution: ND

BIOE 420 (CSE 420) Biomedical Image Computing and Modeling 3 Credits

Biomedical image modalities, image computing techniques, and imaging informatics systems. Understanding, using, and developing algorithms and software to analyze biomedical image data and extract useful quantitative information: Biomedical image modalities and formats; image processing and analysis; geometric and statistical modeling; image informatics systems in biomedicine. This course, a graduate version of BioE 320, requires additional advanced assignments. Credit will not be given for both BioE 320 and BIOE 420.
Prerequisites: MATH 205 and CSE 109
Attribute/Distribution: ND

BIOE 421 (CHE 421) Biomolecular & Cellular Mechanics 3 Credits

Mechanics and physics of cell components, from fundamental biomolecules to the entire cell. The mechanics of proteins and other biopolymers in 1D, 2D, and 3D structures, cell membrane structure and dynamics, and the mechanics of the whole cell. This course is a graduate version of ChE 321 (BioE/Phy 321). The lecture content will be the same as in ChE 321 (BioE/Phy 321), but students enrolled in ChE 421 (BioE 421) will have more advanced assignments. Closed to students who have completed ChE 321 (BioE/Phy 321). Must have graduate standing.

BIOE 424 (MAT 424) Introduction to Organic Biomaterials 3 Credits

Property, characterization, fabrication, and modification of organic materials for biomedical and biological applications; host responses to biomaterials on the molecular, cellular, and system level; general introduction to biosensors, drug delivery, and tissue engineering. Graduate version of BioE 324 requiring additional assignments. Credit is not given for both BioE 324 (MAT 324) and BioE 424 (MAT 424).
Prerequisites: MAT 033

BIOE 425 (MAT 425) Inorganic Biomaterials 3 Credits

Fabrication methods for biomedical implant and devices. Selection of metals and ceramics with specific bulk and surface physical as well as chemical properties. The role of materials chemistry and microstructure. Biocompatibility. Case studies (dental and orthopedic implants, stents, nonporous ceramic filters for kidney dialysis). Graduate version of MAT 325; credit will not be given for both MAT 325 and MAT 425.
Prerequisites: MAT 033

BIOE 426 (MAT 426) Biomimetic and Bio-enabled Materials 3 Credits

This course is a graduate version of BIOE 326 (MAT 326). While the lecture content will be the same as the 300-level course, students enrolled in BIOE 426 (MAT 426) will have more advanced assignments. Closed to students who have taken BIOE 326 (MAT 326). Must have graduate standing in Bioengineering or Materials Science and Engineering.
Attribute/Distribution: ND

BIOE 439 (CHE 439) Neuronal Modeling and Computation 3 Credits

This course is a graduate version of BIOE 339 (CHE 339). While the lecture content will be the same as the 300-level course , students in the 400-level class will be expected to complete an independent term project. Closed to students who have completed BIOE 339 (CHE 339). Must have graduate standing in Bioengineering or Chemical Engineering.

BIOE 441 (CHE 441) Biotechnology I 3 Credits

See the course description listed for BioE 341. In order to receive 400-level credits, the student must do an additional, more advanced term project, as defined by the instructor at the beginning of the course. Closed to students who have taken BioE 341 (CHE 341).

BIOE 442 (CHE 442) Biotechnology II 3 Credits

See the course description listed for BIOE 342 (CHE 342). In order to receive 400-level credit, the student must do an additional, more advanced term project, as defined by the instructor at the beginning of the course. Closed to students who have taken BIOE 342 (CHE 342).

BIOE 447 (CHE 447) Molecular Bioengineering 3 Credits

This course is a graduate version of CHE 344 (BioE 344). While the lecture content will be the same as the 300-level course, students enrolled in CHE 447 will have more advanced assignments. Closed to students who have completed BioE 344 (CHE 344).

BIOE 449 (CHE 449) Metabolic Engineering 3 Credits

This course is a graduate version of BIOE 349. While the lecture content will be the same as the 300-level course, students enrolled in BIOE 449 (CHE 449) will have more advanced assignments. Closed to students who have completed BIOE 349. Must have graduate standing in Chemical Engineering or Bioengineering.

BIOE 450 Special Topics 1-3 Credits

Special topics of study in bioengineering. Permission of instructor.

BIOE 466 (ECE 466) Neural Engineering 3 Credits

Neural system interfaces for scientific and health applications. Basic properties of neurons, signal detection and stimulation, instrumentation and microfabricated electrode arrays. Fundamentals of peripheral and central neural signals and EEG, and applications such as neural prostheses, implants and brain-computer interfaces. Closed to students who have taken BIOE 366, ECE 366, or ECE 466. Students enrolled in the course at the 400-level must complete additional advanced assignments, as defined by the course instructor.

BIOE 468 (ECE 468) Introduction to Biophotonics and Optical Biomedical Imaging 3 Credits

Optical principles, techniques, and instruments used in biomedical research and clinical medicine. Fundamental concepts of optical imaging and spectroscopy systems, and details of light-tissue interaction. Commercial devices and instruments, as well as novel optical imaging technologies in development. Closed to students who have taken BIOE 368, ECE 368, or ECE 468. Students enrolled in the course at the 400-level must complete additional advanced assignments, as defined by the course instructor.

BIOE 490 Thesis 1-6 Credits

Repeat Status: Course may be repeated.

BIOE 499 Dissertation 1-12 Credits

Professors. Tsai-An Hsu, PhD (Northwestern University); Wonpil Im, PhD (Cornell University); Anand Jagota, PhD (Cornell University); Linda J. Lowe-Krentz, PhD (Northwestern University); Svetlana Tatic-Lucic, PhD (California Institute of Technology)

Associate Professors. Bryan W. Berger, PhD (University of Delaware); Javier Buceta Fernandez, PhD (National University of Distance Education); Xuanhong Cheng, PhD (University of Washington); Sabrina S. Jedlicka, PhD (Purdue University)

Assistant Professors. Yevgeny Berdichevsky, PhD (University of California San Diego); Lesley A. Chow, PhD (Northwestern University); Xiaohui Zhang, PhD (University of Miami); Chao Zhou, PhD (University of Pennsylvania)

Professors Of Practice. Lori Herz, PhD (Rutgers University); Susan F. Perry, PhD (The Pennsylvania State University)